# Mechanisms of disrupted homeostasis and kidney injury

> **NIH NIH R01** · BROAD INSTITUTE, INC. · 2024 · $565,177

## Abstract

PROJECT SUMMARY
Diabetic Kidney Disease (DKD) is the leading cause of kidney dysfunction and failure for
more than 400 million patients worldwide. While the high prevalence of obesity is closely
linked to the increased incidence of Type 2 diabetes, hypertension, and kidney failure, the
complex interplay between these conditions is incompletely understood.
Our recent work revealed an important role for a specialized group of cells in the kidney
called TREM2 resident macrophages. These cells appear to increase in numbers in both
mouse and human kidneys in the setting of obesity and diabetes. Therefore, the molecule
TREM2 that is found on the surface of these immune cells may be a therapeutic target for
kidney disease.
The goal of this proposal is to build on our recent discoveries and perform detailed studies
in mouse models and human kidney tissue to gain further insight into whether TREM2
macrophages can protect the kidney from the harmful effects of obesity-driven type
2 diabetes. This work will pave the way for new therapies for diabetic kidney disease
patients, which are greatly needed.

## Key facts

- **NIH application ID:** 10905508
- **Project number:** 2R01DK099465-10A1
- **Recipient organization:** BROAD INSTITUTE, INC.
- **Principal Investigator:** Anna Greka
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $565,177
- **Award type:** 2
- **Project period:** 2014-09-20 → 2028-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10905508

## Citation

> US National Institutes of Health, RePORTER application 10905508, Mechanisms of disrupted homeostasis and kidney injury (2R01DK099465-10A1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10905508. Licensed CC0.

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