PROJECT SUMMARY Neuroendocrinology and metabolism are central to a host of major health issues including obesity, diabetes, hypertension, cardiovascular illnesses, renal disorders and infertility. In this revised renewal, we have addressed the concerns raised in review of our renewal application (see introduction), including strengthening the program for recruiting PhD candidates. The primary goal of UVA’s Research Training in Neuroendocrinology and Metabolism Program is to provide outstanding, state of the art, postdoctoral research training for tomorrow’s basic and clinical scientists in the inter-linked fields of neuroendocrinology and metabolism. Support is requested for 4 postdoctoral training positions per year, for PhD, MD or equivalently qualified young scientists. We strongly believe that hands-on conduct of in-depth research with an experienced mentor, all within a rich and nurturing environment, is the most important component of our Program. We offer a broad repertoire of research opportunities with highly collaborative mentors with rich, diverse backgrounds: PhDs, MDs, and MD-PhDs from 12 different Divisions and Departments. This high quality of mentorship is the key factor in the long-term success of trainees and the training program. Accordingly, we only include mentors who demonstrate a passion for training the next generation of scientists. Research training is enriched through a structured educational framework designed to impart the full complement of knowledge and skills required for a successful research career. This is achieved by providing trainees with a systematized, well-heeled dynamic program that continually evolves with scientific progress, examples include: Seminars, Journal Club, Research in Progress, Didactic Lectures, Grant Brewing Sessions and opportunities for training in courses related to responsible conduct of research and career development. The administrative structure includes an Executive Steering Committee that makes training grant appointments, formally evaluates each trainee’s progress, and manages Program design and direction. To ensure a high level of oversight, a Program Review Committee assesses the operation and performance of the Program and makes formal recommendations regarding programmatic improvement. This Program has a strong record of training scientists of diverse backgrounds, who have gone on to establish successful careers in academic, medical, pharmaceutical, government, and biotechnology environments and to obtain independent extramural funding to support their training. This strong overall record underscores the rich research training opportunities, devoted mentors, and stimulating training environment offered by the Research Training in Neuroendocrinology and Metabolism Program.