Abstract This application requests partial funding for the 2024 Symposium of the Midwest Aging Consortium (MAC). The conference will be held April 28-30, 2024, at the Blackwell Hotel on the Ohio State University campus in Columbus, OH. The expected attendance is 150-200, including basic scientists, physician-scientists, clinicians, and other health professionals. Speakers and attendees will integrate junior and senior investigators and trainees specializing in various scientific disciplines (cell biology, cancer, genetics, medicine, and geriatrics). This conference represents the 5th annual MAC meeting with a unique blend of cutting-edge science in the field of aging. The specific topics to be covered at this conference include: (1) Cellular Senescence and Aging; (2) Cancer and Aging; (3) Metabolism and Aging; (4) Exercise and Aging; (5) Biomarkers of Aging; (6) Stress Response and Aging. We believe that this meeting is unique, timely, and significant because it will bring together recognized experts from more than ten institutions in the Midwest, including the Mayo Clinic, University of Wisconsin, Minnesota, Michigan, Iowa, Indiana, Northwestern, North Dakota, Ohio State, and Illinois-Chicago, which are all leading institutions in aging, cell biology, genetics, and geriatrics. This 5th MAC symposium is designed to disseminate new information and promote the interaction between established and junior investigators. This meeting will provide a framework for novel approaches and future age-related disease research directions.