Project Summary Mount Sinai’s Institute for Exposomic Research requests support for an annually held international series of 5 symposia focused on Exposomics, Aging, and Alzheimer’s disease Across the Life Course. The exposome is the study of all the health relevant environmental factors encountered across life. Exposomics is a complex “big data” science with branches that include climate and health, untargeted chemical assays, satellite remote sensing, wearable devices, and social media mining among other measures. Mount Sinai has been hosting Exposome symposia annually since 2018 and our team has successfully hosted meetings internationally in Europe and Latin America already. Our goals are to advance exposomic science globally in order to accelerate research in exposomics in Alzheimer’s Disease and Related Dementias (ADRD). These symposia will foster new research collaborations and catalyze a critical mass of researchers working in Aging and Exposomics. Many of the attendees, including junior faculty, are or will become future leaders in the exposomics of aging. These conferences will also targeted health disparities around ADRD and promote policy and research initiative designed to address those disparities. Our R13 proposal has multiple highly committed partners already. Our meetings will be held in 5 locations-Japan, Mexico, France, Rwanda and Meharry Medical College, a historically Black College/University. We have strategically designed our program to promote diversity, equity and inclusion in ADRD Exposomic Research and to address the role of environment and aging globally. By doing so, we maximize its impact. Each symposia is preceded by a ½ day workshop (e.g. ArcGIS and mapping the exposome, untargeted chemical assay and their analysis, mining google maps and mining social media platforms are all examples of planned workshops). We will invite prominent speakers from major research institutions. For example several NIH Institute directors as well as the NIH ECHO and All- of-US program directors have been presenters at our symposia). Local experts from the host countries will be prioritized as presenters, and we will include U.S. leaders in exposomic science and leaders in ADRD research from across the country. Our poster sessions will bring together junior scientists with established researchers, and we will use R13 funding for travel awards targeting underrepresented scientists, junior faculty and trainees from developing/middle income countries and the U.S. Each program is evaluated by attendees, and evaluation data will be used to improve each subsequent symposium. We will track our ability to attract diverse participants. We will also track attendees and activities employ a Kirkpatrick Model-based survey to measure participant satisfaction, increases in knowledge, and utilization of exposomics in their research. 1