Overall Summary Differentiating normal from pathological cognitive change and identifying associated risk factors is essential in prevention, early diagnosis, and early intervention for mild cognitive impairment (MCI), Alzheimer's Disease, and Alzheimer's Disease-Related Dementia (AD/ADRD). The goal of The Mobile Toolbox for Monitoring Cognitive and Behavioral Function renewal (MTB2) is to expand the Mobile Toolbox library of brief and sensitive measures to create a comprehensive research platform that can remotely assess neurological and behavioral functions across the lifespan in large-scale studies. The expanded MTB will serve as a form of “common currency” that researchers can use across diverse study designs and populations. We will address the MTB2 goals through the expansion, widespread dissemination, and support of the MTB as follows: 1. Add a validated and normed library of iOS and Android smartphone-based measures to assess non-cognitive domains known to change across the lifespan. The MTB assessment library will add change- sensitive measures of physical, psychological, social, and behavioral constructs known to influence cognitive trajectories and/or prelude MCI and AD/ADRD. New measures will be validated against gold standard measures in healthy adults ages 20-85, clinically validated in a sample of healthy and cognitively impaired adults, and then normed in a nationally representative age-stratified sample. 2. Extend and maintain a software platform to support clinical researchers and software developers in the dynamic, customizable integration of the MTB library into research studies. The MTB enables researchers to select existing measures and contribute new ones, manage study protocols, and receive, store, aggregate, analyze, and (as appropriate) share data. We will curate the existing platform and develop new functionality to gather health and behavior data captured via passive or attachable biosensors on mobile devices. Software code for MTB2 measures, along with protocols, normative data, and analytical pipelines will be made openly available to the research community. 3. Develop and support a growing user base, ensure cost-recovery efforts, and sustain continued development and refinement of the platform. The MTB will accommodate new research-initiated measures and enable de-identified data sharing. A complete customer support facility will be created to encourage potential MTB users to explore and test-drive the MTB. They will have access to an online help system and same-day customer support, which will directly address issues or triage requests to appropriate scientists and software developers, leveraging our experience developing the cost recovery models that currently support the NIH Toolbox and PROMIS measures, ensuring the continuing viability of the MTB.