The Schools of Medicine, Nursing, and Public Health of the Johns Hopkins University are proposing to renew the Johns Hopkins Alzheimer’s Disease Resource Center for Minority Aging Research (JHAD-RCMAR) in response to RFA-AG-23-025. The aims of this application are to: (1) mentor early-stage investigators from under-represented backgrounds in minority aging and health disparities research, with a focus on Alzheimer’s disease (AD) and AD-related dementias (ADRD), using a life course perspective encompassing biological, behavioral, and community factors contributing to cognitive impairment and dementia in older adults from under-represented backgrounds; (2) conduct epidemiological, preventive, and intervention research that addresses AD/ADRD in later life within a multi-level framework that encompasses individuals, families, social networks, and communities; and 3) engage communities and care providers – especially family caregivers, primary care practices, communities of faith, and community organizations – as our partners in recognizing dementia and developing interventions with the potential to prevent cognitive decline and reduce AD/ADRD dementia risk and disparities in minority older adults. The JHAD-RCMAR consists of: (1) a Leadership and Administrative Core whose function is to provide governance and an administrative structure, to support research, to foster interactions between Cores and other Centers and Universities. particularly Historically Black Colleges and Universities, and Minority Serving Institutions, and to ensure RCMAR Scientists develop mentoring relationships across the affiliated departments, schools, and nationally; (2) a Research Education Component to foster diverse junior investigators and mid-career investigators transitioning into ADRD-relevant research through support for individual pilot projects, career mentoring, scholar-to-scholar interactions, and role modeling; (3) a Community-Liaison and Recruitment Core to ensure the relevance of the AD/ADRD research and to increase knowledge of engagement of community members in the research enterprise with the further development of a Community Resource Institute as a venue for community-investigator interaction; and (4) an Analysis Core as a foundation for methodological and statistical training, including education and mentoring in mixed-methods research. An Executive Committee includes community representatives and an External Advisory Committee consists of distinguished investigators with relevant expertise in minority aging, disparities, and AD/ADRD. A pilot project program supported by all Cores to facilitate the development of RCMAR Scientists includes three initial pilot projects focusing on legal needs of Black men with dementia and their care partners; Closing the Black/White wealth gap in cognitive health; and Dementia caregiving experiences for older parents of Asian Indian Origin in US and India. Our renewal reflects our interdisciplinary team’s desire to continu...