PROJECT SUMMARY The proposed conference series, titled “The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved,” will be held annually in the fall (2024-2028). The locations of the 2024-2028 conferences remain to be selected but will be chosen based on several factors in including proximity to minority-serving institutions and communities impacted by cancer disparities as well as the future needs and growth of the conference series. This proposed conference series will be the 17th-21st in an AACR series focused specifically on the science of cancer health disparities. The first conference on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved was held in 2007, then annually from 2009-present. While many conferences on cancer health disparities focus on policy and public health issues or one specific underserved group, the goal of this conference is to feature the full spectrum of research in the field and incorporate presentations on a wide range of medically underserved populations while including perspectives from basic, population, behavioral, computational, translational, and clinical researchers in conjunction with those from patient advocates, government, public health experts, and others. Transdisciplinary interactions and collaborations will be pivotal to advancing the field, stimulating new research, and making progress in reducing and ultimately eradicating cancer health disparities. Additionally, this conference series serves as a platform to facilitate the development of a diverse cancer workforce and to provide educational opportunities to clinicians treating medically underserved patients. Professional development opportunities for early career investigators are available at all levels of the conference from experience as session chairs and program committee members to poster presentations and mentored roundtable discussions. CME credits are available for clinicians seeking to increase their knowledge and skills in providing treatment to ethnic/racial minorities and medically underserved patients.