# ECHO Renewal for the CANOE Study Cohort

> **NIH NIH UG3** · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $1,414,688

## Abstract

ABSTRACT
The overarching goals of this application are to: 1) maintain retention of children in the Vanderbilt CANOE birth
cohort with emphasis on diversity and implementation of the ECHO Cohort Protocol with high fidelity and
conduct new enrollment, and 2) address key questions in the field about one of the most common and
modifiable early life environmental exposures consistently associated with significantly increased asthma risk,
respiratory syncytial virus (RSV) infection, delineating the severity-dependent and age-dependent effects of
RSV infection on asthma risk. This innovative project has significant public health impact, as establishing the
age- and severity-dependent relationship between RSV and asthma is the first and most important step in
disease primary prevention. We propose to address key unanswered questions in the field: the severity- and
age-dependent association of RSV and asthma, and the impact of infection on lung function. In addition, we
will explore the broad impact of the SARS-CoV-2 pandemic on asthma incidence and control in an exploratory
aim, which may provide support for multi-faceted environmental modifications in asthma prevention and
control, and data to inform the potential impact of broad public health interventions.
The birth cohort that this application supports is the Vanderbilt CANOE (Childhood Allergy and the NeOnatal
Environment) study. CANOE is a birth cohort designed to identify and understand how environmental factors
modify the development of the airway epithelium. The study includes the unique longitudinal sampling of the
child airway throughout the first year of life, and annually. The Vanderbilt CANOE study has unique early life
exposure and outcomes ascertainment, including surveillance for RSV and a novel biospecimen repository of
nasal airway epithelial cells. The CANOE cohort also has important information for longitudinal development of
the airway microbiome and the airway epithelium. The proposed research is innovative and timely given the
anticipated licensure of multiple RSV prevention products in the coming year (maternal vaccines and long-
acting monoclonal antibodies for infants). The proposed work represents a novel, multi-faceted approach to
identifying and understanding the influence of severity of RSV infection and age of RSV infection on asthma
risk and lung function. The answers to these questions will be critical to developing prevention strategies and
informing public health expectations for RSV non-pharmaceutical preventive strategies and evaluating potential
long-term value-added benefits of vaccines in preventing lifelong chronic respiratory disease. These data may
not only bolster RSV vaccine acceptability and uptake in the US, but will almost certainly be useful in
evaluating the cost-effectiveness of RSV prevention strategies in low and middle income countries.

## Key facts

- **NIH application ID:** 10907770
- **Project number:** 5UG3OD035517-02
- **Recipient organization:** VANDERBILT UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** Tina V Hartert
- **Activity code:** UG3 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,414,688
- **Award type:** 5
- **Project period:** 2023-09-01 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10907770

## Citation

> US National Institutes of Health, RePORTER application 10907770, ECHO Renewal for the CANOE Study Cohort (5UG3OD035517-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10907770. Licensed CC0.

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