ABSTRACT – Analysis Core Healthy People 2030, a decennial public health roadmap set by the US Department of Health and Human Services, calls for public health research and policy focused on improving health equity, with key objectives related to social determinants of health, including resilience against negative health outcomes. Despite prior Healthy People objectives to address health disparities among different racial/ethnic groups, the conditions of birth, learning, labor, and aging continue to unduly influence health outcomes, further exacerbated by prevalent socioeconomic inequities. Disparities affecting American Indians and Alaska Natives (AI/AN) and Native Hawaiians/Pacific Islanders (NHPI) are exceptionally persistent, and are especially problematic in diseases of aging, such as Alzheimer’s disease and related dementias (ADRD). A key knowledge gap is that methods to identify, diagnose, and risk stratify patients have not been adapted for use in AI/AN and NHPI, who have unique social, environmental, and access pressures influencing ADRD prevalence, diagnosis, and characterization. Thus, specific approaches for studying ADRD in AI/AN and NHPI are urgently needed. This Native Alzheimer’s Disease Resource Center in Minority Aging Research (NAD-RCMAR) is well positioned to enable early-stage investigators to conduct impactful Pilot Studies on ADRD risk and resilience factors in AI/AN and NHPI, by using mentoring and structured analytic techniques designed to yield strong conclusions and serve as preliminary data for grant proposals. The NAD-RCMAR Analysis Core (AnC) is structured to emphasize methods training, mentoring, and support in ADRD research affecting AI/AN and NHPI populations. Our AnC is well positioned to support NAD-RCMAR Scientists with methods mentoring and biostatistics support for Pilot Studies; methods consultation for grant writing; partner with other NAD-RCMAR components to provide didactic instruction; and develop a research resource of datasets focused on ADRD risk and resilience in AI/AN and NHPI. Our Specific Aims are to (1) Collaborate with Research Education Component (REC) to provide mentoring and didactic instruction to NAD-RCMAR Scientists, with a focus on methods for data collection and analysis in risk and resilience of ADRD disparities affecting AI/AN and NHPI; (2) Collaborate with NAD-RCMAR faculty so that NAD- RCMAR Scientists can design, conduct, analyze and interpret high-quality research on risk and resilience disparities in ADRD among AI/AN and NHPI; (3) Provide structured support to NAD-RCMAR Scientists in data management, analysis, and inference; (4) Maintain and develop a database of studies with data on ADRD risk and resilience in AI/AN and NHPI; and (5) Work with RCMAR Coordinating Center to share data and information. Overall, this AnC will help NAD-RCMAR Scientists to maximize scientific rigor while accommodating logistical and methodological challenges in studying ADRD in AI/AN and NHPI. Our overa...