# Revisiting ReCHARGE: ECHO Follow up on Middle Childhood and Adolescence

> **NIH NIH UG3** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $1,109,470

## Abstract

Beginning in fall, 2016, the UC Davis pediatric cohort, ReCHARGE, was funded with the new
Environmental Influences on Child Health Outcomes (ECHO) Consortium that encompassed
close to 80 sites. Now in year 7 of ECHO Phase 1, UC Davis has enrolled ~900 children into
ECHO from three neurodevelopmental groups of children with: autism spectrum disorder (ASD),
developmental delays (DD) without autistic symptoms, and typical development (TD); uploaded
over 55,000 data collection forms to the ECHO Cohort Data Platform, and transferred over 8000
biospecimen aliquots to the ECHO Biorepository, including DNA for SNP arrays, urine for
analyzing novel chemicals from common but understudied household products, and blood for
multiple uses. The UC Davis ECHO team led a number of analysis proposals,
authored/coauthored 40 peer-reviewed papers, with another 50 in-progress. The Team also
contributed to developing ECHO policies and participated in and led various working groups,
such as Neurodevelopment, Chemical Exposures, Epigenetics, as well as Committees on
Publications, Policy Implementation and Evaluation, and others. The ECHO-ReCHARGE cohort
focuses on the ECHO area of neurodevelopment, which is facilitated by the UC Davis MIND
Institute. In ECHO Phase 2, the UC Davis Aim 1 will: examine environmental exposures
including air pollution, greenspace, and home product use; as well as family financial hardship
and parental mental health or substance use problems, in associations with externalizing and
internalizing behaviors, namely, symptoms of ADHD, anxiety and depression at ages 8-20; and
potential modification of exposure-outcome associations by early childhood developmental
diagnosis (ASD, DD, TD), age, sex and puberty status. Aim 2 will evaluate the environmental
exposures listed above along with childhood exposure to PFAS and plasticizers, for
associations with longitudinal trajectories of the above behavioral and emotional outcomes, as
well as cognitive skills. Aim 3 will implement the final ECHO protocol with high fidelity, maximize
retention, and adhere to all ECHO policies, IRB, HIPAA and other regulations. UC Davis will
continue to contribute broadly to the ECHO infrastructure; advance the science through analysis
and publications; work to retain participants; and actively participate and play leadership roles in
this high-profile, unique program to discover underlying risk and resilience factors for childhood health and development.

## Key facts

- **NIH application ID:** 10907811
- **Project number:** 5UG3OD023365-09
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** Deborah Hall Bennett
- **Activity code:** UG3 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,109,470
- **Award type:** 5
- **Project period:** 2016-09-21 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10907811

## Citation

> US National Institutes of Health, RePORTER application 10907811, Revisiting ReCHARGE: ECHO Follow up on Middle Childhood and Adolescence (5UG3OD023365-09). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10907811. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*