# Human Pangenome Reference

> **NIH NIH U41** · WASHINGTON UNIVERSITY · 2024 · $1,761,233

## Abstract

PROJECT SUMMARY (Project 1: Human Pangenome Reference)
The draft pangenome reference provides a solid foundation upon which to build a mature, more complete human
pangenome that better serves humanity. In the next phase of the Human Pangenome Reference Consortium
(HPRC), we will identify individuals of broad biogeographical ancestry to include in the reference and ensure that
the global population equitably benefits from representation within the pangenome. We will provide the
community with a stable foundation for myriad downstream uses and value-added resources by building and
validating haplotype-resolved reference assemblies, creating alignments of these assemblies, and creating gene
annotations of each assembly. We will support core formats and tooling that make it possible to obtain and work
with the pangenome and coordinate the community of downstream tool builders who will ultimately determine
the success of the resource. We will coordinate these efforts with the broader scientific community to develop
and maintain a pangenomic tool ecosystem that is flexible, adaptable and responsive to user needs. We will
solicit and respond to community feedback to incorporate ‘lessons learned’, and identify and respond to
challenges to adoption of the pangenome. To maximize its downstream utility and use, and truly function as a
reference for all science, all samples included in the core resource will be consented for open access sharing.
For high-priority communities who opt to retain control of their own data, we detail a strategy for transferring
technology and expertise to these groups so they can work alongside us and benefit from the pangenome data,
resources and methods. We will continue to work closely with the embedded HPRC ethical, legal, and social
implications (ELSI) team of scholars for guidance on issues such as consent and participant community
engagement, and we will continue to initiate and foster collaborations with sister consortia and international
partners to develop a democratized resource that is representative of, and useful to, the global populations
populations it seeks to represent.

## Key facts

- **NIH application ID:** 10907974
- **Project number:** 2U41HG010972-06
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** Ting Wang
- **Activity code:** U41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,761,233
- **Award type:** 2
- **Project period:** 2019-09-18 → 2029-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10907974

## Citation

> US National Institutes of Health, RePORTER application 10907974, Human Pangenome Reference (2U41HG010972-06). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10907974. Licensed CC0.

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