# Ubiquitination, Intestinal Homeostasis and Cancer

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $426,199

## Abstract

Abstract
Adult intestinal tissues are maintained in a normal functional state despite rapidly proliferating and
differentiating intestinal epithelial cell populations that replenish the epithelium layer every 6-7 days. Intestinal
epithelial cells reside in close association with both adaptive and innate immune cells of the gut. A reciprocal
and dynamic dialogue among these components maintains intestinal homeostasis and is mediated in part by
paracrine cytokine and interleukin networks. Intestinal inflammation predisposes intestinal epithelial cells (IEC)
to malignant transformation via incompletely understood mechanisms. We have generated a novel knock-in
mouse line that spontaneously develops perturbed IEC differentiation, gut elongation, and have a high
susceptibility to colon cancer. These mice provide us with a unique opportunity to discover the key
inflammatory mediators that regulate intestinal homeostasis and drive IEC transformation. Using
transcriptomic, proteomic, genetic epistasis and cellular approaches, our preliminary data implicate selected
immune cytokines in these processes.

## Key facts

- **NIH application ID:** 10908477
- **Project number:** 5R01CA266755-03
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** AVERIL I MA
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $426,199
- **Award type:** 5
- **Project period:** 2022-09-01 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10908477

## Citation

> US National Institutes of Health, RePORTER application 10908477, Ubiquitination, Intestinal Homeostasis and Cancer (5R01CA266755-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10908477. Licensed CC0.

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