PROJECT SUMMARY Core C: Administrative core An Administrative Core is proposed to support the administrative needs of the Program Project Grant. The major functions of the Core will be to provide a structure for decision making, organization of regular PPG meetings, mechanisms for internal and external advice and review, and effective utilization of resources. This Core will be Co-Directed by Drs. Glass and Witztum. Dr. Glass, Dr. Witztum, Dr. Evans, Dr. Loomba and Dr. Benner (PIs of Projects 1, 3, 2, and Core B respectively) will form an executive committee for routine decision making. An internal advisory committee consisting of Dr. Nicholas Schork, Dr. Alan Saltiel and Dr. Tatiana Kisseleva will provide both administrative and scientific advice. An external advisory group will be constituted to review the scientific program on an annual basis. The external advisory group will be selected to include expertise in NASH, atherosclerosis, inflammation, gene expression and statistics. The Administrative Core will be responsible for ensuring that the PPG conforms to the Resource Sharing Plan, the Sharing of Model Organisms and the Data Sharing Plan. The Administrative Core will also be responsible for preparation of the Annual Non Competing renewal.