PROJECT SUMMARY: OUTREACH (This core is identical to all three partnering institutions) The overall goal of the Outreach Core is to implement and evaluate an evidence-based, theory-informed, multi- level, clinical trial and cancer genomics education program (CTC-GEP) that addresses the determinants for African American (AA) and Latinx participation in clinical trials and cancer genomics studies. The CTC-GEP is informed by the Increasing Minority Participation in Clinical Trials (IMPaCT) program, an efficacious clinical trials navigator program implemented at the University of Alabama at Birmingham O’Neal Comprehensive Cancer Center. We will build on the findings of this program and extend application of the patient navigation model to participation in clinical trials and genomic cancer research. A cadre of lay community navigator professionals will be trained and serve as clinical trials navigators (CCN) to deliver two unique types of toolkits comprised of evidence-based educational resources on research participation (low-tech) and culturally tailored educational and multiple media content via mobile tablet technology (high-tech). The CCNs will deliver these toolkits and provide logistical support to participants interested in participating in cancer research in rural and urban community health and academic research centers within the Partnership catchment areas. The CTC-GEP will also address AA and Latinx beliefs, values, attitudes, concerns, and preferences related to participation in research, such as privacy, trust, and safety. An evaluation plan based on a logic model will be applied throughout the project. Outcome measures will be assessed through pre- and post- surveys. The outcomes of the CTC- GEP include a) intentions to participate in research, b) awareness and knowledge about research, and c) genomic research and clinical trial enrollment. Additionally, having a Joint Clinical and Biomedical Research Advisory Roundtable (JCAR) guided, clinical community navigation and education program will lead to increased awareness, opportunity and participation in genomic research and clinical trials among a diverse population of AAs and Latinx. The rationale for this Core, intended to facilitate research and not conduct research, is to identify effective strategies to facilitate research participation among AA and Latinx populations. Thus, the activities outlined in this proposal are congruent with the strategies in the Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) RFA listed for the Outreach Core.