The OSCTR Professional Development (ProfDev) Core is essential to addressing the Oklahoma Shared Clinical and Translational Resources (OSCTR) goals of mentoring new and early-stage investigators across the clinical and translational research (CTR) pipeline to independence, providing training and mentoring of CTR scientists to focus on the health issues of our populations, and building capacity for CTR research within our community partners. During the first funding cycle, the ProfDev Core supported programs that provided mentored training opportunities spanning summer research experiences for undergraduate and graduate/professional students to a master’s degree in clinical and translational science (CTS). In addition, we developed the Translating Practice into Research program, providing intensive CTR training to rural, academic, and tribal clinicians from Oklahoma and other IDeA states to increase their ability to be valuable members of productive, multi-disciplinary research teams. In the current cycle, we added an online Certificate in CTS program, benefiting those who cannot travel to Oklahoma City for courses regularly. Throughout these two cycles, the mission of the Core has evolved to prioritize increasing mentoring capacity and effectiveness in the state. We recently established the Oklahoma Center for Mentoring Excellence (OCME), allowing the OSCTR to enhance the development of CTR researchers and provide a formal mentor training program to support the capacity-building missions of the IDeA programs in the region. OCME activities have included workshops tailored to broad audiences of individuals interested in developing their mentoring skills, which have been attended by more than 200 faculty members and provided the training and experience needed to effectively guide the professional development of CTR investigators. The OCME has provided a validated mentoring framework for junior investigators supported by the OSCTR. With this renewal, we will utilize this pool of certified mentors to provide targeted, one-on-one research and career development support to OSCTR Scholars. The ProfDev Core will continue to build on institutional efforts to increase the competitiveness of our clinical investigators for NIH career development awards and provide additional mentoring to active K-award recipients. The ProfDev Core will continue to support successful educational efforts of the OSCTR that increase the ability of our rural and community members to access training resources, including the Certificate program. This includes new support for the development of a CTR education and training online toolkit within the Gateway to Research in Oklahoma portal that will provide a consolidated site for dissemination of content produced across the OSCTR Cores, including training videos, presentations, and tip sheets focused on clinicians, research staff, and community stakeholders. Together, these activities will assist our supported Scholars, Mentors, Invest...