PROJECT SUMMARY: TRANSLATIONAL CORE FOR THERAPEUTIC AND DIAGNOSTIC DEVELOPMENT The Translational Core for Therapeutic and Diagnostic Development (TCTDD) will enhance the research programs of a growing number of R01 funded investigators engaged in basic science research by providing powerful new data science and high throughput data analysis support. Currently, NEI R01 grants supported by this P30 grant are engaged in basic biomedical research (T0 research) with explicitly stated goals of translation of research findings for new methods of diagnosis, treatment, and prevention of eye diseases (T1 research). The TCTDD core will provide Data Science and Artificial Intelligence (AI) services for pre-processing, analysis and visualization of basic research data (molecular, cellular and imaging) to provide deeper mechanistic insights and synergistic opportunities for moving towards translational research (Aim 1). The TCTDD core will also provide technology-driven, automated services to bolster the research throughput for generating high quality, rigorous research data which will expand the breadth and depth of basic science research while accelerating related translational research (Aim 2). The long-term goal is to accelerate discoveries that easily transit from bench-to- bedside.