# Center for Molecular Imaging Technology & Translation (CMITT)

> **NIH NIH P41** · YALE UNIVERSITY · 2024 · $1,339,345

## Abstract

Project Summary / Abstract for the Center for Molecular Imaging Technology and Translation
The Center for Molecular Imaging Technology and Translation (CMITT) is a National Center for Biomedical
Imaging and Bioengineering located within the Gordon Center for Medical Imaging (GCMI) at the Massachusetts
General Hospital. Working within the interdisciplinary environment (e.g., imaging and data sciences; image
reconstruction, processing and AI; pharmacokinetics; radiochemistry) of the Gordon Center, the aim of the CMITT is
to develop, validate and disseminate cutting-edge imaging technologies that take advantage of the game-changing
capabilities afforded by simultaneous acquisition of PET and MR. CMITT approaches PET/MR as a truly synergistic
modality, with novel radiochemistry, kinetic modeling, quantitative methods, image reconstruction and AI that exploit
properties of PET and MR signals. Thus CMITT advances the methodology of PET/MR and covers the entire range
of radiochemistry/radiopharmacy to image formation and processing including tomographic reconstruction and
estimation/quantitation, paving the way for research applications and clinical translation. Our pioneering work during
the initial funding cycle, Y1-4, of our P41 in quantitative PET/MR, has provided solutions to some of the most vexing
problems affecting PET/MR, including reliable and accurate corrections for attenuation and involuntary subject motion
(TR&D 1 in Y1-4). We have provided unique contributions to PET quantitation and image reconstruction by using
deep learning (TR&D 2 in Y1-4). We have also advanced novel radioligands and new molecular measurements,
starting from first concept to actual application (TR&D 3 in Y1-4). Accordingly, in this renewal application, we are in
a strong position to propose and develop new field-leading technologies pertaining to Molecular Imaging using PET
and MR. The TR&D1 of the renewal develops and delivers multi-parametric quantitative PET/MR imaging
technologies that not only enable physiological high-impact novel PET/MR but will also benefit standalone MR
research. The TR&D2 of the renewal develops an innovative artificial intelligence-based pipeline of data processing
in PET/MR, including image reconstruction, transfer learning, and uncertainty estimation. The TR&D3 of the renewal
uses the developments achieved in TR&Ds 1&2 to translate applications of PET/MR from physiological concept to
measurements in animal models and then on to first-in-human studies. The National Resource provides a unique
environment with an interdisciplinary team of highly accomplished scientists, engineers, and clinicians with diverse
expertise in multiple modalities and disciplines that supports service use of the Center's facilities by imaging scientists
throughout the country as well as Canada and Australia. CMITT will provide extensive training opportunities for
students, post-doctoral fellows, and faculty, and seeks to advance the field of molecular imaging of n...

## Key facts

- **NIH application ID:** 10909226
- **Project number:** 7P41EB022544-08
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** Georges El Fakhri
- **Activity code:** P41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,339,345
- **Award type:** 7
- **Project period:** 2017-09-30 → 2028-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10909226

## Citation

> US National Institutes of Health, RePORTER application 10909226, Center for Molecular Imaging Technology & Translation (CMITT) (7P41EB022544-08). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10909226. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*