# Pathobiology of Occlusive Vascular Disease

> **NIH NIH T32** · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · 2024 · $541,186

## Abstract

This A1 resubmission is for continuation of a multi-disciplinary postdoctoral research training program in
cardiovascular sciences that annually supports six (MD, DDS, DVM, PhD) research fellows. The program has a
rich and sustained record of success training young scientists and future leaders over the past 40 years. Of
trainees in the past ten years, 95% (37/39) are currently in science/medicine; 38% are from an underrepresented
population in science, 64% are women, 8% are physician scientists, 45% received independent funding while
supported by the program, 55% assumed faculty postions upon graduation, and trainees average two peer-
reviewed publications per year while in the program. Here we provide plans to sustain and enrich this robust
cardiovascular research training program with postdoctoral training in the well-funded, interactive laboratories of
41 internationally recognized leaders and cardiovascular scientists from the Departments of Biochemistry &
Structural Biology, Cell Systems & Anatomy, Endodontics, Mechanical Engineering, Medicine, Neurology,
Neurosurgery, Pathology, Pharmacology, Physiology, Population Health Sciences, and Surgery at the University
of Texas Health Science Center at San Antonio. In brief, principal components of the training program include:
(1) active participation with graded responsibility in the research laboratory of experienced investigators; (2) a
commitment to collaboration and the use of multidisciplinary research approaches; (3) continuing research-in-
progress seminars, and dissemination of findings at national/international meetings and in print; (4) integrated
journal club series on topics in cardiovascular science; (5) didactic courses and seminars in the responsible
conduct of research, scientific rigor and reproducibility, scientific communication, and grantsmanship/peer
review; (6) a group mentoring environment with rigorous mentorship plans; (7) preparation of an individual
development plan (IDP) and the comprehensive, routine evaluation of trainee progress; (8) submission of an
independent grant; (9) development of scientific networks and continuing training in career stewardship; (10) the
continued evaluation and teaching of mentoring skills to faculty preceptors and trainees; and (11) the active
recruitment of meritorious trainees and faculty that well reflect workforce diversity. Program research and training
focus on eight overlapping investigative themes: (1) Cardiac Arrhythmias, Fibrosis and Failure; (2) Coronary
Artery Disease and Atherosclerosis; (3) Cerebrovascular Disease and Stroke; (4) Diabetes, Metabolism and
Obesity; (5) Renovascular and Neurogenic Hypertension; (6) Neural Cardiovascular Reflexes; (7) Cardiorenal
Dysregulation; and (8) Bacterial and Viral Heart Disease. Integration of these themes is essential to
understanding the mechanisms of cardiovascular disease. Given the complexities, and mortality associated with
cardiovascular disease, the goal of this training program ...

## Key facts

- **NIH application ID:** 10909232
- **Project number:** 5T32HL007446-43
- **Recipient organization:** UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
- **Principal Investigator:** Jean Chrisostome Bopassa
- **Activity code:** T32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $541,186
- **Award type:** 5
- **Project period:** 1990-07-01 → 2027-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10909232

## Citation

> US National Institutes of Health, RePORTER application 10909232, Pathobiology of Occlusive Vascular Disease (5T32HL007446-43). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10909232. Licensed CC0.

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