# The Pittsburgh Scientific and Data Research Center for the COPE-AKI Consortium (Pitt-SDRC)

> **NIH NIH U01** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $730,807

## Abstract

ABSTRACT
Acute kidney injury (AKI) and chronic kidney disease (CKD) are “interconnected” syndromes in
which each influences the other. CKD is a risk factor for AKI and AKI contributes to the
development or progression of CKD, end-stage renal disease (ESRD), cardiovascular symptoms,
and death, not to mention recurrent AKI episodes and impaired health-related quality of life
(HRQoL). Processes of care after AKI hospitalization have been found to be suboptimal, with
lack of continuity of care, delayed follow-up and suboptimal medication management
exacerbating the risks of adverse outcomes. In addition, optimal pharmacologic therapy, such as
blockade of the renin-angiotensin-aldosterone system (RAAS) or sodium-glucose cotransporter
type 2 (SGLT2), has not been defined. The Caring for OutPatiEnts after Acute Kidney Injury
(COPE-AKI) Consortium will address these important gaps in knowledge of optimal
management of patients surviving an episode of moderate (stage 2) or severe (stage 3) AKI. The
goal of the COPE-AKI Consortium will be to develop and test interventions to optimize
processes of care and identify key pharmacologic and non-pharmacologic interventions to
reduce morbidity among these high-risk patients. The Center for Clinical Trials & Data
Coordination (CCDC) at the University of Pittsburgh is well poised to serve as the Scientific and
Data Research Center (SDRC) for the COPE-AKI Consortium. Our multidisciplinary
investigative team has a history of collaboration, wealth of experience and expertise, including
expertise in acute and chronic kidney disease, critical and translational care, medication
management, design of clinical trials, telehealth, clinical and data coordination, project
administration support, biostatistics, measurement of patient-reported outcomes, health
services research and patient engagement. Our goal is to serve as the Scientific and Data
Research Center for the COPE-AKI Consortium. Specifically, we will 1) establish an efficient and
rigorous process for designing the Consortium study, including protocol development and
adaptation of an existing web-based data collection system; 2) provide comprehensive expertise
for data management and analysis within the Consortium; and 3) provide program coordination
and administrative support throughout all phases of the study.

## Key facts

- **NIH application ID:** 10909276
- **Project number:** 5U01DK130010-04
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** Kaleab Z Abebe
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $730,807
- **Award type:** 5
- **Project period:** 2021-07-19 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10909276

## Citation

> US National Institutes of Health, RePORTER application 10909276, The Pittsburgh Scientific and Data Research Center for the COPE-AKI Consortium (Pitt-SDRC) (5U01DK130010-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10909276. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*