# Optically Induced Anisometropias

> **NIH NIH R01** · UNIVERSITY OF HOUSTON · 2024 · $755,025

## Abstract

PROJECT SUMMARY/ABSTRACT
Soon after birth, most infants develop the optimal refractive error (i.e., “clinical” emmetropia) in both eyes that
is maintained throughout childhood and into adult life. However, for reasons not currently understood, a
significant and rapidly increasing proportion of the population develop myopia, or nearsightedness. Because of
structural changes that take place as the eye becomes myopic, even low degrees of myopia pose a significant
risk for multiple blinding conditions. As a consequence, myopia is now one of the leading causes of permanent
visual impairment in the world. Additionally, myopia represents a substantial economic burden. In addition to
lost productivity, billions of dollars are spent annually on optical corrections and pathologies caused by myopia.
The long-term goal of our research program is to provide a better understanding of the etiology of common
forms of myopia, juvenile and early adult-onset myopia, and to develop effective treatment strategies that
reduce the burden of myopia. The specific aims of our proposed research are to determine how visual
experience affects refractive development, to characterize the operational properties of the vision-dependent
mechanisms that regulate eye growth, and to explore new pharmaceutical approaches to eliminate myopia.
Our purpose is to generate knowledge that can be applied to the human eye; however, many of the required
experiments cannot be conducted in humans. Therefore, these experiments will be conducted using rhesus
monkeys. Previous studies in our lab and others show that characteristics of light, such as intensity,
wavelength, and duration of exposure, influence eye growth. Potential mechanisms include alterations in
retinal and choroidal visual cascades and ocular remodeling, particularly of the sclera, the outermost coat of
the eye. Preliminary data also show that prostaglandin analogs and alpha-adrenergic agonists influence eye
growth. Here, controlled rearing strategies, rigorous optical and biometric techniques, and histopathological
investigation will be used to determine: 1) the effects of duration and dosing of red light exposure on in vivo
eye growth and myopia and on in vitro human scleral fibroblast culture and 2) whether prostaglandin analogs
and alpha-2 adrenergic agonists can slow the development of myopia. The role of scleral fibroblast activity,
scleral remodeling, and intraocular pressure in eye growth will be examined. The proposed experiments focus
on fundamental issues concerning the manner in which visual experience influences refractive development.
Findings will be important in determining how and to what extent visual experience contributes to the genesis
of common human refractive errors. More importantly, the results of these studies will potentially provide the
scientific foundation for novel treatment and management strategies for the most common forms of myopia in
children to prevent and slow the progression of myopia, incr...

## Key facts

- **NIH application ID:** 10909303
- **Project number:** 5R01EY003611-41
- **Recipient organization:** UNIVERSITY OF HOUSTON
- **Principal Investigator:** Lisa A Ostrin
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $755,025
- **Award type:** 5
- **Project period:** 1981-02-01 → 2027-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10909303

## Citation

> US National Institutes of Health, RePORTER application 10909303, Optically Induced Anisometropias (5R01EY003611-41). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10909303. Licensed CC0.

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