The Bioimaging Resource Core (BRC) is a critical component of the Wake Forest Older Americans Independence Center (WF OAIC). It provides leadership, scientific expertise, and instrumental support in quantitative imaging, including CT, MRI, DXA, PET, and ultrasound, critical to the WF OAIC’s research theme: Integrating pathways affecting physical function for new approaches to disability treatment and prevention. The BRC is well integrated with other OAIC cores and supports investigators’ use of imaging to characterize body and brain structure and function. In the present cycle, the BRC facilitated 4 OAIC scholars, 8 pilot and development projects, contributed to 80 original papers, and 19 new NIH awards, including 5 to early-career investigators. The BRC and the WF OAIC Biostatistics and Research Information Systems Core partnered with the WF Alzheimer’s Disease Research Center to harmonize storage, processing, archiving, and access of imaging data for body and brain to facilitate research integrating the biology of aging and mobility with brain health. The BRC also developed, validated, and implemented innovative image acquisition and analysis methods for muscle, fat, bone, and brain phenotypes. The Specific Aims of the BRC for the new cycle are to: 1) Support pilot, development, and externally-funded research projects with quantitative imaging phenotypes for use in observational and intervention research evaluating factors affecting pathways to mobility disability; 2) Develop and validate new imaging measures relevant to pathways affecting physical function. These will include trabecular and cortical bone microarchitecture acquired with a new high-resolution peripheral quantitative computed tomography (HR- pQCT) scanner; CT-radiomics of muscle, fat, and bone; “CT-body-age” and “MRI-brain-age” and functional brain network metrics associated with mobility; and 3) Apply imaging techniques in support of WF OAIC programmatic goals by: training researchers focused on disability treatment and prevention to integrate imaging methods; collaborating with other OAIC cores to develop multidisciplinary, translational projects; and disseminating data and methods for use by the national research community. In the first year of the next cycle, BRC will support 16 studies including 1 BRC-led research Development Project, 2 Pilot studies (1 led by a REC Scholar), and 13 Externally-funded studies. The BRC will be led by three highly experienced, independently successful investigators: Leon Lenchik, MD, Christina Hugenschmidt, PhD and Ashley Weaver, PhD. They have complementary skills and expertise and strong records of collaborative scientific and administrative achievements. They will ensure the achievement of the BRC goals and its contributions to the overall success of the WF OAIC.