# Role of methylation-dependent pathways in aging and stress

> **NIH NIH R01** · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $613,602

## Abstract

Metabolic cycles provide building blocks and energy currency for the cell, but also signaling
molecules that regulate diverse physiological responses from differentiation to aging. The
metabolite S-adenosylmethionine (SAM) is one such factor that is used to regulate gene
expression in the stress response, a key part of the aging process. We have discovered that
individual SAM synthases has distinct effects and hypothesize that uncovering the mechanisms
regulating local production of SAM will produce novel insights into stress-responses and aging.

## Key facts

- **NIH application ID:** 10909356
- **Project number:** 5R01AG053355-07
- **Recipient organization:** UNIV OF MASSACHUSETTS MED SCH WORCESTER
- **Principal Investigator:** Amy Karol Walker
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $613,602
- **Award type:** 5
- **Project period:** 2017-09-01 → 2028-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10909356

## Citation

> US National Institutes of Health, RePORTER application 10909356, Role of methylation-dependent pathways in aging and stress (5R01AG053355-07). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10909356. Licensed CC0.

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