# Reciprocal longitudinal associations between brain function and alcohol use trajectories in adolescents and young adults

> **NIH NIH K99** · WASHINGTON UNIVERSITY · 2024 · $173,200

## Abstract

PROJECT SUMMARY/ABSTRACT
Alcohol use is a global health problem that often begins in adolescence/young adulthood. Despite extensive
research efforts, effective preventative and treatment measures remain elusive. While bi-directional associations
between alcohol use and brain function form the cornerstone of prominent neurobiological theories of addiction,
the reciprocal relationship between alcohol use and brain function remains underexplored. This 5-year K99/R00
proposal is designed to address this fundamental gap in knowledge, through the novel application of cutting-
edge techniques which overcome many of the limitations of between-subject cross-sectional designs, including
low reliability and small effect sizes. It is hypothesized that neurocognitive mechanisms of decision making which
underly elevated risk taking in adolescence (i.e., elevated reward processing relative to lower cognitive control)
contribute to alcohol use initiation in adolescence, as well as escalation and maintenance in young adults, and
that the consumption of alcohol in turn influences these same mechanisms, thereby promoting future use.
Crucially, this proposal is designed to support the applicant’s transition to independence through: 1) technical
training in advanced longitudinal and machine learning analysis, and the collection and analysis of precision
functional mapping (PFM) data, 2) training in assessments of alcohol use behavior in young adults, and 3)
professional and career development, including leadership and mentorship, grantsmanship, professional
networking, publication, and scientific presentations. Aim 1 (K99) will assess prospective long-term associations
between reward, cognitive control, and alcohol use in two large extant datasets of adolescents and young adults
(IMAGEN: ages 14-22, N=2000; ABCD: ages 9-18, N=11,000). Analyses will use multivariate neural signatures
of these processes, which are more reliable and sensitive to individual differences than regional estimates. Aims
2&3 (K99/R00) will collect the novel ALC-21 sample – a sample of college students who engage in heavy
episodic drinking (N=24), who will be scanned repeatedly (8-10 scans each) over a semester, immediately
following periods of elevated use (e.g., 21st birthday) and reduced use. The use of precision functional mapping
(PFM) – studying an effect with large within-subject variation by acquiring large quantities of imaging data per
subject – maximizes the neuroimaging signal, spatial resolution, and measurement reliability. PFM results in
robust and reliable within-subject brain-behavior associations. A subset of the full sample (N=5) will be collected
for Aim 2, and will be used to test the short-term effect of heavy episodic drinking on reward and cognitive
control. The remainder of the sample will be collected during the R00 portion for Aim 3, which will assess bi-
directional short-term associations between reward, cognitive control, and alcohol use. Together, these studies
wi...

## Key facts

- **NIH application ID:** 10909834
- **Project number:** 5K99AA030808-02
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** David A Baranger
- **Activity code:** K99 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $173,200
- **Award type:** 5
- **Project period:** 2023-09-01 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10909834

## Citation

> US National Institutes of Health, RePORTER application 10909834, Reciprocal longitudinal associations between brain function and alcohol use trajectories in adolescents and young adults (5K99AA030808-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10909834. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*