PROJECT SUMMARY - ADMINISTRATIVE CORE The Administrative Core will provide the infrastructure required to ensure efficient coordination, integration, planning, and evaluation of all agent discovery activities associated with the proposed CAP-IT Center. The Core provides an integrated multidisciplinary framework for scientific collaboration among the participating members and Shared Resources at FCCC. To facilitate productivity, the Administrative Core will provide fiscal management and clerical support, as well as ensure scientific rigor, data reproducibility, attention to important biological variables, transparency, and consistent communication. Importantly, the Administrative Core will serve as a liaison with the NCI and other Specialized CAP-IT Centers, and leverage the support of the Informatics Core to effectively engage with the Data and Resource Coordinating Center. Active participation of CAP-IT members in meetings, workshops and activities of the CAP-IT Network will be coordinated through the Administrative Core. These activities will be accomplished according to four specific aims to: 1) Maintain an effective framework of well-integrated multidisciplinary research activities by applying strong communication and organizational skills, and frequently monitoring research progress; 2) Promote trans-Network collaborations by coordinating and participating in CAP-IT Network meetings, and organizing inter-programmatic seminars and workshops; 3) Engage early-stage investigators in precision cancer prevention – interception research and disseminate findings and capabilities to the scientific community; and 4) Evaluate the progress of the proposed CAP-IT Center using standard deliverables and defined metrics and milestones of success. The Leadership Team, comprised of accomplished investigators with expertise in hereditary cancer syndromes, target validation, agent screening, in vivo efficacy testing, and informatics, will provide oversight of all aspects of the research projects, and make informed decisions at critical junctures of the discovery pipeline. In close consultation with the NCI, the FCCC CAP-IT will leverage its unique resources and technical expertise to fuel the discovery of agents for cancer prevention and interception within the CAP-IT Network and beyond.