ABSTRACT- Facility Management, Maintenance and Operations Core (Core 1) To serve the primary mission of the Duke RBL, it is imperative that the facility itself operates to the highest operational standards. The overall goal of this Aim is to ensure that we can maintain reliable and uninterrupted facility functionality. To achieve this goal, we focus on several critical elements: the facility must be safely and effectively operated through a functional and seamless management process, inculcating a culture of safety that permeates throughout the entire organization; the systems that are vital to the operation of the facility must be well-maintained, and where appropriate the scheduled replacement of key systems must be planned prior to any likely systems failure (i.e. before the end of the lifespan of the system or equipment). Finally, and consistent with the aforementioned culture of safety, it is essential that facility meets or exceeds all of the regulatory standards that are required for all of our systems and equipment. The goals of this Facility Management, Maintenance and Operations Core (Core 1) are to 1) provide expert management and oversight of the BSL-3 space; 2) ensure proper preventative maintenance of all critical systems; and 3) ensure continuous compliance with all applicable regulatory standards. This Core is foundational to the safe and effective operation of the Duke RBL core, and as with all programs dedicated to managing and minimizing risk, embodies a culture of iterative improvement and the highest of operating standards.