Project Summary The Administrative Core at the Cancer Prevention-Interception against MGUS Progression (CAP-MGUS) Center will provide administrative, scientific, fiscal, and logistic oversight over the whole Center. The Core will also provide clerical support, coordinate interactions between the Bioinformatics Core and Research Projects, and organize regular investigator meetings inside and outside the CAP-MGUS Center. It will bridge the research activities within the CAP-MGUS Center and the NCI CAP-IT program officials to promote collaboration, ensure that the CAP-MGUS Center’s work contributes effectively to issues relevant to the CAP-IT mandates, and maximize dissemination and application of Center discoveries. The Administrative Core has five primary objectives. First, the Core will manage and communicate the research activities within the CAP-MGUS Center. Second, the Administrative Core will promote collaborations on MGUS prevention and interception between the Research Projects and the Bioinformatics Core within the CAP-MGUS Center and collaborations between the Center members and outside investigators. Third, the Administrative Core will organize annual meetings and other network activities. Fourth, the Administrative Core will conduct effective and contextually appropriate outreach. Fifth, the Administrative Core will evaluate existing Research Projects and develop new ones. The CAP-MGUS Center will be one of the few national research consortium centers dedicated to both IgM-MGUS and non-IgM MGUS prevention and interception. The Administrative Core will bring together top experts in MGUS and related cancers and other blood disorders, provide scientific and logistic oversight to Center activities, disseminate scientific knowledge and discoveries, and liaise between Center members and outside stakeholders.