# Animal, Behavior and Tissue Core

> **NIH NIH P01** · UNIVERSITY OF ARIZONA · 2024 · $398,480

## Abstract

Abstract
Development and utilization of aged and genetically engineered mouse models are crucial to understanding
the roles of specific genes in age-related hearing loss (ARHL). We will require strain-specific aged (senescent)
mice that are not available commercially or are produced at the NIA-supported facility at the NIH,
http://www.nia.nih.gov/research/dab/aged-rodent-colonies-handbook. All projects, Core C and Core D within
the proposed PPG makes extensive use of these aged mice, and utilize a variety of genetic approaches to
study the structural and functional remodeling in the auditory neural pathways. The proposed PPG will require
the use of gene-targeted mouse models to study the mechanistic underpinning in the aging auditory system.
The purpose of the mouse core is to provide services for the establishment of a strain-specific aged mouse
colony and the generation and management of gene-targeted and transgenic mice. Founder mice will be
identified, bred, and maintained in an animal facility at UNR. Additionally, several mouse lines will be bred and
aged and supplied for experiments proposed in all three projects, Core C and Core D. The Core will also be
responsible for maintaining and distributing mouse lines to each individual project. This will provide the most
cost effective sharing and utilization of the mouse models. In addition, the Core will also cryopreserve critical
lines in case of an inadvertent loss. Finally, the Core will be a resource for other laboratories interested in
mouse models of ARHL.

## Key facts

- **NIH application ID:** 10910234
- **Project number:** 7P01AG051443-07
- **Recipient organization:** UNIVERSITY OF ARIZONA
- **Principal Investigator:** EBENEZER N YAMOAH
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $398,480
- **Award type:** 7
- **Project period:** 2023-09-01 → 2028-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10910234

## Citation

> US National Institutes of Health, RePORTER application 10910234, Animal, Behavior and Tissue Core (7P01AG051443-07). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10910234. Licensed CC0.

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