CORE A: ABSTRACT The Administrative Core (Core A) supports the work of this SToP Cancer SPORE. The Administrative Core and its leadership team led by Dr. Yeh will be responsible for strategic planning, management and commitment of all project and core resources, and ensuring compliance with all university, federal, and specific NCI/NIH grant regulations and requirements, including timely communications and consultations with the National Cancer Institute. Core A will oversee and facilitate all interactions with SPORE investigators and collaborators external to UNC Lineberger. Additionally, Core A will coordinate all necessary meetings to administer the programmatic operation of the SPORE, including meetings of the Executive Steering Committee, Internal Advisory Board, External Advisory Board, and SToP Cancer SPORE investigators. Through this series of meetings, the Core assumes responsibility for scientific oversight of the SPORE and will also oversee the activities of the Developmental Research and Career Enhancement Programs. These functions will assist the SPORE leadership in ongoing planning and evaluation of the program to ensure progress towards the accomplishment of the proposed aims and resolve scientific disputes that arise. Core A will coordinate all human subject research- related activities for compliance with institutional and federal regulatory requirements. In addition, Core A will have overall fiscal responsibility for the SPORE to ensure cost-effective and efficient use of resources, including the substantial institutional commitment to projects, infrastructure and recruitment allocated to leadership, which approaches $7.5M over the 5 years of the SPORE. Through these activities, the UNC SToP Cancer SPORE Administrative Core supports an exceptional team of pancreatic cancer translational researchers as they seek to understand this deadly disease and its treatment, advance new technology, and develop junior faculty into translational research leaders.