# Molecular Dysregulation in Fuchs Corneal Endothelial Dystrophy

> **NIH NIH R00** · TRUSTEES OF INDIANA UNIVERSITY · 2024 · $238,905

## Abstract

Fuchs Endothelial Corneal Dystrophy (FECD) is a blinding disease that affects 4% over the age of 40 in 
the United States. There is no cure for this condition. Corneal tranplantation is the prevalent treatment. 
With the aging population, there is increasing scarcity of donor tissues. In addition, tranplant failures due 
to graft rejections occur in 10-25% of corneal transplantations. This proposal focuses on identifying 
previously understudied molecular signaling pathways in FECD. Successful completion of the specific 
aims in this proposal can lead to alternative therapies for FECD.

## Key facts

- **NIH application ID:** 10911337
- **Project number:** 5R00EY032974-04
- **Recipient organization:** TRUSTEES OF INDIANA UNIVERSITY
- **Principal Investigator:** Rajalekshmy Shyam
- **Activity code:** R00 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $238,905
- **Award type:** 5
- **Project period:** 2021-09-01 → 2026-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10911337

## Citation

> US National Institutes of Health, RePORTER application 10911337, Molecular Dysregulation in Fuchs Corneal Endothelial Dystrophy (5R00EY032974-04). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10911337. Licensed CC0.

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