# PDX Core

> **NIH NIH U54** · WISTAR INSTITUTE · 2024 · $177,298

## Abstract

Project Summary – PDX Core B
The PDX Core provides major resources to the program investigators, including melanoma PDX, melanoma
cell lines and 3D models such as organoids, spheres, and spheroids, to explore new therapies. Our melanoma
PDX pre-clinical platform encompasses >500 different tumors representing all clinical, biologic, and genetic
groups of the disease. The primary focus of the PDX Core is to establish, bank and distribuite new PDX and
PDX-derived models. The PDX Core also coordinates the characterization the pre-clinical melanoma models at
at the biological (e.g. growth and metastasis) and molecular (e.g. DNA- and RNA-sequencing, and protein
expression) levels. The core maintains a master cell bank, conducts quality control of specimens and derived
models and monitors for mouse pathogens. The core is also the central facilitator for exchanging PDX within
the PDXNet and coordinates collaborations with other investigators within the program, the overall PDXNet
and outside scientists. The core coordinates data storage, data sharing and distribution to other investigators
within the program.
The PDX Core is available to train investigators of the program in all biological assays and models. Overall,
this core will provide efficient and high-quality service to all investigators within this PDTC. The PDX Core is
also available to assist investigators withinPDXNet and collaborators as requested.
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## Key facts

- **NIH application ID:** 10911348
- **Project number:** 5U54CA224070-06
- **Recipient organization:** WISTAR INSTITUTE
- **Principal Investigator:** Meenhard F Herlyn
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $177,298
- **Award type:** 5
- **Project period:** 2017-09-01 → 2028-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10911348

## Citation

> US National Institutes of Health, RePORTER application 10911348, PDX Core (5U54CA224070-06). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10911348. Licensed CC0.

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