# Examining Sleep, Circadian Rhythms, and Cognitive Functioning in Older Adults at Risk of Dementia

> **NIH NIH F31** · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · 2024 · $38,352

## Abstract

PROJECT SUMMARY / ABSTRACT
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that leads to cognitive and functional
impairment, and is a leading cause of death and disability in aging populations. As there is no cure for AD,
current research is focused on understanding early cognitive and behavioral changes to aid in earlier diagnosis
and treatment implementation. Older adults are prone to experiencing cognitive changes and changes in sleep
function and circadian rhythms, which regulate timing of physiology and behavior across the 24-hour day.
Sleep and circadian rhythm disturbances negatively impact cognitive functioning, and are associated with
increased risk of cognitive decline and AD dementia. Subjective cognitive decline (SCD) is one of the earliest
observable changes preceding objective mild cognitive impairment (MCI), and often signals the need for a
cognitive evaluation. There is a paucity of research examining circadian rhythm disturbances in adults
experiencing SCD, and it is not well understood how circadian rhythm disturbances may relate to changes in
cognitive functioning in this population. Associations with other factors known to relate to sleep and cognitive
functions, such as stress, are also understudied in this group. Examining circadian rhythm timing, their
associations with cognitive functions, and the influence of stress on these relations in SCD may reveal
predictive factors or treatments of cognitive decline targeted to the circadian timing system.
 The proposed study will examine circadian rhythm timing and cognitive functioning in adults over 50 who
(a) are experiencing SCD, (b) have MCI, and (c) are cognitively intact. Dim light melatonin onset (DLMO)
testing, actigraphy, and neuropsychological measures will be used to compare circadian rhythm timing and
cognitive functioning across these groups (N=90; 30 in each group). This study aims to examine: (1)
differences in circadian rhythm timing between study groups; (2) associations between circadian rhythm timing
and cognitive functioning in these three groups; and (3) whether perceived stress moderates these
associations. It is hypothesized that adults with SCD and MCI will exhibit advanced circadian phase, increased
fragmentation, and increased sleep irregularity compared to age-matched cognitively intact adults; that these
circadian disruptions will be associated with worse cognitive performance on objective neuropsychological
tests; and these associations will be moderated by stress ratings. Through this fellowship, the applicant will
gain valuable experience and hands-on training in sleep and neuropsychological research methods and
analyses, enabling her to comprehensively examine sleep-related risks of cognitive decline and AD.
Furthermore, she will build a network through training and research engagement at Boston University, Brigham
and Women’s Hospital, and Massachusetts General Hospital. Together, these experiences will provide her
with a deep...

## Key facts

- **NIH application ID:** 10911786
- **Project number:** 5F31AG081066-02
- **Recipient organization:** BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
- **Principal Investigator:** Celina F McDowell
- **Activity code:** F31 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $38,352
- **Award type:** 5
- **Project period:** 2023-07-01 → 2027-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10911786

## Citation

> US National Institutes of Health, RePORTER application 10911786, Examining Sleep, Circadian Rhythms, and Cognitive Functioning in Older Adults at Risk of Dementia (5F31AG081066-02). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10911786. Licensed CC0.

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