# The Sociostructural Implementation Science Coordination Initiative

> **NIH NIH R24** · NORTHWESTERN UNIVERSITY · 2024 · $974,769

## Abstract

We have the biomedical tools necessary to prevent HIV and improve the health of people living with HIV, yet
achievement of the Ending the HIV Epidemic goals requires sociostructural interventions that address social
determinants of health that contribute to inequities. Evidence-based sociostructural interventions exist that
have a direct impact on PrEP, care-related, and viral suppression outcomes, yet they have been much less
studied than individual-level interventions and their implementation poses unique methodological and
institutional challenges. Determining how sociostructural interventions can reduce health inequities, including
implications for implementation and sustainment, is an urgent public health research priority. The
Sociostructural Implementation Science Coordination Initiative (SISCI) hub will bring the best of Dissemination
and Implementation (D&I) Science to collaborate with the Companion R01s to coordinate data harmonization,
foster opportunities for cross-site learning, and coordinate research, capacity building, and dissemination
efforts. We will grow the capacity of both researchers and implementers to apply D&I models and methods for
developing, testing, and implementing sociostructural interventions. SISCI investigators and consultative team
are nationally recognized experts in HIV D&I science and have a strong record of coordinating HIV D&I
projects and providing tools and training to the field. The SISCI aims to (1) Assist the companion RO1s through
collaboration, knowledge sharing, and expert consultation on D&I science and social determinants of health
models and methods. We will coordinate in person and virtual communications between companion R01s and
provide tailored methodological support to the projects based on collective needs and opportunities. (2)
Integrate implementation and effectiveness data across R01 studies to collect cross-project data and perform
integrated analyses. Using shared decision making, we will identify common data elements (CDEs) for
collections across projects and plan for integrated analyses. We will deploy data coordination infrastructure to
collect cross-project data and perform integrated analyses—whenever possible obtaining administrative data to
allow new generalizable knowledge beyond what individual projects have studied. We will disseminate findings
on implementation determinants and strategies using our popular HIV implementation science website and
newsletter, conference presentations, and a special journal issue of Companion R01 and other sociostructural
project findings. (3) Advance the field of sociostructural interventions to reduce HIV disparities by developing
and offering a combined D&I science and sociostructural training tailored to early career investigators and
implementation partners. We will further grow the capacity of the field by conducting a scoping review to build a
compendium of promising and proven implementation strategies for sociostructural interventions....

## Key facts

- **NIH application ID:** 10912076
- **Project number:** 5R24MH134305-02
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **Principal Investigator:** Nanette Dior Benbow
- **Activity code:** R24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $974,769
- **Award type:** 5
- **Project period:** 2023-09-01 → 2028-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10912076

## Citation

> US National Institutes of Health, RePORTER application 10912076, The Sociostructural Implementation Science Coordination Initiative (5R24MH134305-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10912076. Licensed CC0.

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