# Core 2: Biospecimen, Metabolomics, and Pathology Core

> **NIH NIH P50** · WASHINGTON UNIVERSITY · 2024 · $121,075

## Abstract

PROJECT SUMMARY/ABSTRACT
The goal of the Biospecimen, Metabolomics, and Pathology Core (BMP Core) is to create a federated, multi-
institutional resource to provide high-quality, clinically annotated biospecimens, metabolomic analyses, and
expert pathology review to all research projects in this SPORE application as well as future SPORE-sponsored
DRP and CEP projects, while serving as an unparalleled biospecimen resource to the broader endometrial
cancer research community. The Core will provide specific tissue and biosample-related services for each
SPORE project. In addition, the BMP Core will prospectively build a biospecimen resource bank at WUSTL,
OUHSC, and UNM by identifying cases of new and recurrent endometrial cancer at the participating institutions
and facilitating the consent and procurement process. Tissue and fluid biospecimens from these patients will
be collected, processed, and stored by leveraging the extensive infrastructure of existing biorepositories at the
participating institutions. Clinical data will be collected prospectively by integrating with and extending existing
clinical databases. Interactions with the Biostatistics Core will ensure interoperability of data tables maintained
at each institution. The BMP Core will provide access to the world-class Center for Metabolomics and Isotope
Tracing at WUSTL. Validated methods for sample processing and preservation, focused on optimizing
metabolic analyses, will be provided to increase the scientific utility of all biospecimens collected. A
transparent and equitable mechanism to publicize existing biospecimen resources and evaluate any request
for their use will be implemented. As such, the BMP Core will supplement existing cancer center resources
with focused expertise and effort to comprehensively collect, annotate, quality review, and distribute
biospecimens specifically for translational endometrial cancer research.

## Key facts

- **NIH application ID:** 10912625
- **Project number:** 5P50CA265793-02
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** Ian S. Hagemann
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $121,075
- **Award type:** 5
- **Project period:** 2023-08-23 → 2028-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10912625

## Citation

> US National Institutes of Health, RePORTER application 10912625, Core 2: Biospecimen, Metabolomics, and Pathology Core (5P50CA265793-02). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10912625. Licensed CC0.

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