# Data Harmonization and Analysis Core

> **NIH NIH P50** · UNIVERSITY OF COLORADO DENVER · 2024 · $414,263

## Abstract

PROJECT SUMMARY/ABSTRACT
DATA HARMONIZATION AND ANALYSIS CORE
In the last six years, the United States has witnessed enormous changes concerning the public acceptance of
cannabis. In short, cannabis and hemp products are widely available in North America. A critical but
unexplored aspect of cannabis legalization is the extent to which the health effects of cannabis products
depend on the ratio of THC and CBD, how endocannabinoids may mediate these effects, and how these
effects may vary across the lifespan. The endocannabinoid system (ECS), which is a combination of CB1 and
CB2 receptors as well as a number of endogenous ligands (2-AG, AEA) and lipid mediators, changes
dramatically over the lifespan and likely mediates the effects of cannabinoids on the brain and immune system.
To understand the neurocognitive and health effects of THC and CBD, it is imperative to understand their
effects on the ECS. The Data Harmonization and Analysis Core (DHAC) will harmonize the clinical data,
neurocognitive data, and the measurement of THC, CBD, metabolites, and endocannabinoids in blood to
understand how THC and CBD influence the ECS and how changes in the ECS may mediate the effects of
THC and CBD across the lifespan. To that end, the DHAC will develop and deploy a system for the support of
the data collection, data harmonization, data analysis and data sharing needs of the RM-CRC (Aim 1). The
DHAC will also harmonize clinical, cannabinoid and metabolite data, endocannabinoid and lipid mediator data
from seven existing R01s (n=1359) in order to enable advanced machine learning (ML) and deep learning (DL)
analyses to identify a panel of analytes that will be examined broadly in the RM-CRC and beyond (Aim 2). The
DHAC will also conduct specialized analyses of the harmonized P50 project data to construct and test cross-
groups simultaneous structural equation models describing how the effects of THC and CBD on the ECS and
the association with downstream neurocognitive and clinical variables change across the lifespan (Aim 3).
Finally, the DHAC will conduct analyses of ABCD data to examine the effects of THC and CBD in adolescents
and to determine if ECS analytes are related to trajectory of brain development and substance use and provide
a platform for future ML analyses of harmonized neuroimaging, clinical, and biological data to determine how
THC and CBD and the ECS are associated with changes in structural and functional measures of connectivity
in the brain (Aim 4).

## Key facts

- **NIH application ID:** 10912682
- **Project number:** 5P50DA056408-02
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** VINCE D CALHOUN
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $414,263
- **Award type:** 5
- **Project period:** 2023-09-01 → 2028-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10912682

## Citation

> US National Institutes of Health, RePORTER application 10912682, Data Harmonization and Analysis Core (5P50DA056408-02). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10912682. Licensed CC0.

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