# Cannabidiol and Older Adult Cannabis Users: A Randomized, Placebo Controlled Study

> **NIH NIH P50** · UNIVERSITY OF COLORADO DENVER · 2024 · $446,278

## Abstract

PROJECT SUMMARY/ABSTRACT
 PROJECT 3: OLDER ADULT STUDY
Recent epidemiological data indicates a 10-fold increase in cannabis use among older adults (65+
years). Given this rise in use, an important public health question is how cannabis use might impact physical
and cognitive health in older individuals, especially since they are at increased risk of mild cognitive impairment
(MCI) and Alzheimer’s dementia (AD). This is additionally important with the rapidly aging population in the
U.S., the prevalence of MCI and AD, and the enormous mortality, morbidity, and socioeconomic costs of
associated with age-related cognitive decline. There is compelling evidence that older adults use cannabis to
treat chronic pain, sleep problems, and anxiety, and it is possible that cannabis use may decrease the
“polypharmacy” effect often associated with aging. In addition, animal studies suggest that cannabidiol (CBD)
and low doses of ∆9-tetrahydrocannabinol (THC) may be neuroprotective, reverse cognitive decline, and be
associated with lower levels of neurodegeneration in subcortical areas. Conversely, high doses of THC may be
harmful, with acute deleterious effects on cognition and motor control (e.g., risk of falling).
Key biological mechanisms that may help explain how cannabinoids differentially affect outcomes are age-
associated changes in inflammation and in the endocannabinoid system (ECS). Research shows that cannabis
(specifically CBD) has anti-inflammatory properties, and inflammation is in turn positively associated with sleep
problems, anxiety, and pain. Similarly, there are links between CBD and THC and particular endocannabinoids
(i.e., arachidonoyl ethanolamide [anandamide, AEA] and 2-arachidonoylglycerol [2-AG]), which are
differentially related to sleep, anxiety and pain. A mechanistic exploration of inflammatory biomarkers and
endocannabinoids could help elucidate the mechanisms of action of THC and CBD in older adults and
potentially more broadly.
The main goal of this project is to investigate these mechanisms and outcomes by randomly assigning
older adults interested in cannabis use to either hemp-derived CBD/+THC, CBD/-THC, or placebo
in an 8 week randomized controlled trial. This design will determine 1) impacts of THC and CBD on
inflammatory and endocannabinoid biomarkers and 2) if these mechanistic changes are associated
with the impact of cannabis on anxiety, sleep, and pain, and 3) the harm to benefit ratio in terms of
acute (impaired balance, impaired cognition) and longer term (polypharmacy, sleep, pain) outcomes.

## Key facts

- **NIH application ID:** 10912693
- **Project number:** 5P50DA056408-02
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** Angela Bryan
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $446,278
- **Award type:** 5
- **Project period:** 2023-09-01 → 2028-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10912693

## Citation

> US National Institutes of Health, RePORTER application 10912693, Cannabidiol and Older Adult Cannabis Users: A Randomized, Placebo Controlled Study (5P50DA056408-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10912693. Licensed CC0.

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