# Mechanisms of Cognitive Control Impairment in ME/CFS and PASC-ME/CFS

> **NIH NIH R01** · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $463,290

## Abstract

ABSTRACT
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a symptom-based diagnosis characterized
by severe debilitating fatigue, cognitive dysfunction, and widespread pain. Most cases of ME/CFS begin with a
viral infection or involve multiple exposures to pathogens over time. Soon after the onset of the COVID-19
pandemic, a significant portion of patients infected with SARS-CoV-2 developed chronic symptoms that
overlap greatly with those of ME/CFS. Among the post-acute sequelae of COVID-19 (PASC), “brain fog”
symptoms have been widely reported including in patients with mild initiating infection. Many PASC patients
meet the diagnostic criteria for ME/CFS after 6 months of ongoing symptoms (referred to herein as PASCME/CFS). Given the growing number of SARS-CoV-2 infections, the disease burden on individuals with
ME/CFS and PASC-ME/CFS, and the challenges associated with these conditions such as rehabilitation and
workforce disruptions, elucidating the mechanisms of cognitive deficits in ME/CFS and PASC-ME/CFS is of
clear

## Key facts

- **NIH application ID:** 10912805
- **Project number:** 5R01NS133905-02
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** H Hamdi Eryilmaz
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $463,290
- **Award type:** 5
- **Project period:** 2023-09-01 → 2028-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10912805

## Citation

> US National Institutes of Health, RePORTER application 10912805, Mechanisms of Cognitive Control Impairment in ME/CFS and PASC-ME/CFS (5R01NS133905-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10912805. Licensed CC0.

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