# Research Core

> **NIH NIH P50** · JOHNS HOPKINS UNIVERSITY · 2024 · $571,246

## Abstract

PROJECT SUMMARY
Decades of research has failed to address Indigenous drug and other substance use inequities in the United
States. These persistent challenges call for new systems and methods to turn the tide on Indigenous substance
use prevention, programs, and policies. The Research Core will serve as a central resource for methods support
and analyses for CIRCLE's proposed research and evaluation projects designed to build resources and evidence
for culture as a core source of healing and prevention of substance use morbidity and mortality disparities
resulting from centuries of colonizer-based racial trauma and oppression. The Research Core is led by a team
of Indigenous and allied leadership who will provide operational support in Indigenous research methodologies;
community partnership and culturally responsive engagement; substance use epidemiology; longitudinal,
quantitative, qualitative, and mixed-methods analyses; multilevel and mixture modeling; implementation science;
and data management, sovereignty, and stewardship in line with CIRCLE's overall aims and objectives. In
addition, the Research Core will advance four methods innovation projects designed to: (1) conceptualize and
operationalize “culture” as a key construct for addressing problematic substance use within and across
Indigenous communities and settings; (2) characterize novel outcomes and measurement approaches for
concepts of pre-addiction and recovery in Indigenous populations; (3) enhance understanding of heterogeneity
in interventions, implementation, and policies to inform precision approaches to substance use research with
Indigenous communities; and (4) operationalize the Indigenist Ecological Systems Model through creation of a
repository of measures and associated resources. The Research Core will also support innovative pilot work by
early-career investigators from diverse disciplines and helps them develop pilot research into robust lines of
extramurally funded research. Finally, the Research Core will support dissemination of the CIRCLE's
methodological advances and research findings in collaboration with the Administrative Core.

## Key facts

- **NIH application ID:** 10913549
- **Project number:** 5P50DA058619-02
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Emily Haroz
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $571,246
- **Award type:** 5
- **Project period:** 2023-09-01 → 2028-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10913549

## Citation

> US National Institutes of Health, RePORTER application 10913549, Research Core (5P50DA058619-02). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10913549. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*