Contact PD/PI: Jarvik, Gail P. Project Summary/Abstract There is a national shortage of medical genetics scientists needed for the implementation of precision medicine, and the discovery of treatments for hereditary diseases. Since its beginnings in the late 1950s, the UW Medical Genetics Training Program has served as the linchpin between the clinical and molecular sciences that has propelled this institution to a position of academic leadership. Our graduates have made outstanding contributions to the body of knowledge of genetic disease and occupy top faculty positions throughout the international medical genetics research community. The UW Program offers comprehensive research and didactic training in human genetics and genomics for physicians following completion of residency training, and for Ph.D.'s in the basic sciences who seek a broader, translational approach to human genetics and genome sciences. Training focuses on highly collaborative mentor-based, research laboratory experience and is complemented with courses, seminars, clinical conferences, journal club, and participation in national meetings. As they progress, trainees are encouraged to apply for individual fellowship awards. A diverse faculty with interests in clinical, mathematical, population, biochemical, molecular and developmental genetics, bioinformatics, and genomics provides a unique environment for preparing our trainees for careers in academic medical genetics. The fifty-six participating faculty are primarily drawn from the two Medical Genetics units in the Departments of Medicine and Pediatrics, and the Department of Genome Sciences. We have improved our training program during the last funding period with : 1) a new combined 4-year Pediatrics-Medical Genetics residency 2) new faculty mentors in the Adult and Pediatric Divisions of Medical Genetics 3) renewal of established, externally-funded research programs and 4) new multidisciplinary research projects such as the Brotman Baty Institute for Precision Medicine, a new clinical site in the NIH Undiagnosed Diseases Network, and a sequencing center for the All of Us research program. 5) improved recruitment and support of underrepresented minority postdoctoral fellows. A specific focus of our program is to diversify the medical genetics workforce by attracting underrepresented minority or disabled trainees to careers in medical genetics. With the increasing integration of genetics into all medical specialties, we request continued support for four funded positions per year for five years to enable the UW Medical Genetics Postdoctoral Training Program to continue its successful mission of launching academic, research-focused careers in medical genetics and genomics.