Administrative Core Project Summary/Abstract Administrative Core will provide executive oversight and administrative support for the construction of atlases of cellular senescence for bone marrow, breast, colon, and liver tissue types by the Washington University Cellular Senescence Tissue Mapping Center (WU-SN-TMC). We will also provide fiscal oversight and infrastructure for communications across the three Cores, namely Biospecimen Core (BC), Biological Analysis Core (BAC), and Data Analysis Core (DAC), and for scientific collaborations within the Cellular Senescence Network (SenNet) and other companion NIH initiatives. The Administrative Core will administer a Pilot Project program to draw on the best emerging scientific ideas and technologies to understand the biological mechanisms governing senescence and advance the mission of the WU-SN-TMC and the entire SenNet. The Administrative Core leadership team has a long history of participating in, and taking leadership roles within, NIH-sponsored, multi-institutional networks; we will build on these experiences to work closely with the Consortium Organization and Data Coordination Center (CODCC), technology development projects, and other Tissue Mapping Centers (TMCs) to ensure the overall success of WU-SN-TMC and NIH SenNet program.