# ECHO Laboratory Core at Vanderbilt for Integrated Sample Biobanking and Processing

> **NIH NIH U24** · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $13,799,987

## Abstract

SUMMARY
Early-life environmental exposures (e.g., social-environmental, parental risk factors, nicotine, diet, infection) are
increasingly implicated in the early pathogenesis of childhood diseases that have life-long consequences.
Mechanisms linking these exposures to longer-term outcomes remain limited. In 2016, the NIH established the
Environmental influences on Child Health Outcomes (ECHO) Program, a collaborative multi-dimensional
research initiative to characterize the impact of early-life environmental factors on childhood health (>70 cohorts,
>50K participants). While targeted assays within ECHO are likely to lead to disease-specific insight, broad,
comprehensive, unbiased assessment of the molecular space for novel discovery—a key mission of ECHO—
will necessitate centralization of biobanking efforts/laboratory management with capability for high-throughput
“OMICs”/non-“OMICs” assay as well as novel assay development, bioinformatics, and cloud architecture/data
sharing for collaborative science. In response to RFA-OD-22-016, Vanderbilt will address this need by
establishing the ECHO Laboratory Core at Vanderbilt for Integrated Sample Biobanking and Processing
(ELVIS). ELVIS facilitates the collection and processing of biospecimens; manages the biorepository; performs
a wide range of biospecimen assays (including novel development), and coordinates metadata and assay data
transfer to the Coordinating Center. ELVIS is organized in core “resources” to provide leadership/integration to
manage ECHO biobanking, assay performance, and data delivery: (1) administrative/LIMS/biobanking; (2)
metabolomics; (3) proteomics; (4) nucleic acid assessment; (5) metagenomics; (6) bioinformatics/study design.
We are uniquely positioned for this initiative, leveraging Vanderbilt’s unique long-term strategic investment in
functional biobanking and assay: (1) large-scale, reliable biorepository receipt and laboratory management
(“LIMS”) capability (>350K patients currently with biospecimens; many other NIH funded biobanks); (2) nationally
recognized systems for clinical metadata capture (REDCap, REDBrics; used in NIH initiatives, like All of Us); (3)
cutting-edge laboratory cores with capability for novel assay development/validation. We will establish
harmonized protocols and workflow for ECHO cohort biospecimen collection and tracking infrastructure from the
point of sample collection to long-term storage (Aim 1); perform high-quality, well-powered multi-OMICs and
targeted assays to identify molecular correlates of disease trajectories in early life (Aim 2), and provide
comprehensive data management platform to facilitate integrated data analysis (Aim 3). ELVIS is an ideal
mechanism for ECHO given (1) deep, funded experience in handling the requisite sample sizes in banking and
high-throughput assay, including quality assurance measures; (2) prior track record in ECHO to ensure ECHO-
specific metadata collection, curation, and harmonization; (3) secure metho...

## Key facts

- **NIH application ID:** 10914237
- **Project number:** 5U24OD035523-02
- **Recipient organization:** VANDERBILT UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** Suman Ranjan Das
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $13,799,987
- **Award type:** 5
- **Project period:** 2023-09-01 → 2030-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10914237

## Citation

> US National Institutes of Health, RePORTER application 10914237, ECHO Laboratory Core at Vanderbilt for Integrated Sample Biobanking and Processing (5U24OD035523-02). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10914237. Licensed CC0.

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