# Development of Ubiquitin-Independent Degraders

> **NIH NIH R01** · UNIVERSITY OF FLORIDA · 2024 · $826,413

## Abstract

Project Summary
Degraders are chemical dimerizers that recruit a target protein (TP) to an E3 Ubiquitin
(Ub) ligase. In favorable cases, this results in TP poly-Ubiquitylation and subsequent
destruction by the proteasome. Degraders are difficult to develop because of the
requirement that the degrader promote significant protein-protein interactions between
the TP and E3 Ub ligase in such a way that a TP lysine residue is placed appropriately to
attack the activated Ub molecule. Here we propose to develop a new class of degraders
that will recruit TP directly to the proteasome. We anticipate that this mechanism of
action will result in potent TP destruction without the need for Ubiquitylation, which, in
turn, will make the development of these degraders far more straightforward.

## Key facts

- **NIH application ID:** 10914808
- **Project number:** 5R01CA290247-02
- **Recipient organization:** UNIVERSITY OF FLORIDA
- **Principal Investigator:** Thomas J. Kodadek
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $826,413
- **Award type:** 5
- **Project period:** 2023-09-01 → 2028-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10914808

## Citation

> US National Institutes of Health, RePORTER application 10914808, Development of Ubiquitin-Independent Degraders (5R01CA290247-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10914808. Licensed CC0.

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