Abstract Core A: Program Administration The mission of the Administrative core is to maintain a cohesive program through facilitating interactions between the three projects and the investigators with the program director. Administrative assistance will be given to the projects and cores to enable them to function efficiently and seamlessly across the Penn School of Medicine, the School of Dental Medicine, and the Wistar Institute. The Administrative core will organize the monthly lab group meetings at which the ongoing research will be discussed. This core will also be responsible for organizing the Henle symposium, which will be a core part of this program and provide a mechanism by which we can link this symposium with the external advisory meetings. Thus, it will also be responsible for organizing all meetings of program leaders and the annual meetings of the Internal and External advisory committees. The Administrative core will be the conduit through which communications and materials will be exchanged with external laboratories. The appropriate permits for transfer of infectious agents (C.D.C., U.S.D.A., and F.D.A.) will be filed and maintained by the administrative core. All MTAs for the program investigators between Penn and other institutions will also be handled by the administrative core. The submission of manuscripts, progress reports, preparation of figures, review of presentations and posters for meetings will also be expedited by the core.