Project Summary: Resource Core 4 (RC4): Technological Assessment and Solutions Core Advances in the uses of engineered technologies and AI, including electronic mobile digital health (EMDH) technologies in health care, hold great promise for improving the older adult well-being and the care of frail older adults. The overarching goal of the Technological Assessment and Solutions Core (RC4) is to develop a novel ecosystem that promotes the development, testing, implementation, and dissemination of novel technologies and new uses of artificial intelligence for frailty-related purposes. This ecosystem will be created by bringing engineers, bioengineers, Gerontologists, Geriatricians and other clinical investigators together into built infrastructure that facilitates the development and testing of novel approaches to health care in frailty. This core will bridge the existing deep expertise in clinical investigation related to frailty to the deep expertise in EMDH technologies, robotics, and AI that exists at Johns Hopkins. Examples of projects that could be supported by this core include 1) robotic assistance with medication 2) treatment adherence the development of novel mobility and fall prevention technologies, 3) measurement improvements in frailty diagnostics through technology-assisted measurement of gait, activity, and other functional signals; 4) leveraging AI to build frailty assessments from these signals are also envisioned, and 5) remotely deployed technological interventions and measurement modalities could provide rich opportunities to expand reach to underserved older adults. This resource core, in collaboration with RC1, 2, and 3, proposes to support 2 pilot studies in this proposal. The specific aims of RC4 are: 1) to provide state-of-the-art engineering and technology application expertise to facilitate and support a broad array of translational frailty research; 2) to provide access to relevant technologies, and the necessary infrastructure to study frailty; 3) to facilitate the translation of RC4 frailty- related and focused technologies and uses of AI into intervention- or prevention-focused clinical studies in collaboration with the leadership of other resource cores; 4) to provide training, mentorship, and guidance to a diverse group of the most promising junior investigators who can contribute to frailty research, and to assure that RC4-developed technology are accessible to underserved populations of older adults; 5) To provide access to business development as relevant and local and national visibility for RC4-related science and activities.