# University of Michigan O'Brien Kidney Translational Resource Center (MKTC)

> **NIH NIH U54** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $937,567

## Abstract

ABSTRACT – CENTER OVERVIEW
The main goal of the University of Michigan O'Brien Kidney Translational Resource Center (MKTC)
is to provide an effective translational research pipeline to develop novel, mechanistic treatment
strategies for patients with kidney diseases. The center will support all basic and patient-oriented kidney
research investigators using a 3-pronged approach: Enable investigators to investigate the molecular
causes and endpoints of acute and chronic kidney diseases; Dissemination and support of the most
modern and powerful systems biological approaches for all investigators to help them effectively identify
novel and robust biomarkers, endpoints and targets for diagnosis and treatment of AKI and CKD; Expert
analysis and integration of cohort and systems data for our research base investigators through the use
of sophisticated bioinformatics and database integration that promote identification of specific pathways
and targets for treatments for individuals or groups of subjects with AKI and CKD.
The Center's aims are to:
 1) Introduce, stimulate and apply state-of-the-art systems biological approaches to kidney disease
 research investigators through the use of sophisticated but user-friendly genetic, transcriptomic,
 proteomic, metabolomic and lipidomic approaches through the Applied Systems Biology Core;
 2) Enhance the understanding of complex kidney diseases and the multi-scalar data sets that
 accompany systems biological approaches to their functional implications regarding kidney
 disease development, diagnosis, progression and therapeutic potential through the Data Analytic
 Services Core (DASC);
 3) Serve as national resource and expand worldwide outreach efforts via Nephroseq, Nephrocell
 and tranSMART;
 4) Use the Student Programs and robust enrichment programs to entice trainees and faculty into
 kidney research, improve diversity, equity and inclusion and support researchers in their ongoing
 kidney research.
 5) Share best practices and resources with the other National Resource Centers under the U54
 consortium and work with Data Coordinating Center to enable widespread dissemination.

## Key facts

- **NIH application ID:** 10914996
- **Project number:** 5U54DK137314-02
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Subramaniam Pennathur
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $937,567
- **Award type:** 5
- **Project period:** 2023-09-01 → 2028-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10914996

## Citation

> US National Institutes of Health, RePORTER application 10914996, University of Michigan O'Brien Kidney Translational Resource Center (MKTC) (5U54DK137314-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10914996. Licensed CC0.

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