Project Summary/Abstract - Administrative Core The overarching goal of the Administrative Core is to lead, manage, and harmonize all aspects of the IU O’Brien U54 National Resource Center (NRC) and ensure that that the IU O’Brien resources are shared nationally. This goal will be accomplished through collaboration with the U24 O’Brien National Coordinating Center (NCC) to: 1) Prioritize external requests from the kidney research community for the efficient utilization of the two IU O’Brien Biomedical Resource Core (BRC) resources consisting of the Intravital Microscopy BRC and the Molecular Imaging BRC; 2) engage in activities to enhance national outreach and impact of the IU O’Brien NRC; 3) educate the community about kidney research; 4) monitor and evaluate emerging advances in imaging science in conjunction with the IU O’Brien Resource Development Core; 5) asses imminent research needs of the kidney research community; 6) organize a broad range of educational programs to provide a pipeline of future kidney researchers, assist early stage investigators, and attract new investigators from outside the kidney research community; and 7) develop pathways that enhance the diversity of the kidney research community. The Administrative Core will serve as the portal for communication and coordination with the O’Brien U24 NCC, other U54 O’Brien NRCs in the consortium, and the kidney research community at large. The IU O’Brien Resource Center will provide a unique and powerful service to the kidney research community. Together, the assets of the two IU O’Brien BRCs and the Resource Development Core coordinated by the Administrative Core will allow investigators in the kidney research community to test and refine key hypotheses as they pertain to a vast array of kidney diseases. Therefore, the proposed research service is significant, because it is expected to aid the kidney research community in identifying critically needed biomarkers of disease progression, optimizing preclinical studies, and developing specific and targeted therapeutic interventions for a wide range of kidney diseases.