# UCLA IDDRC

> **NIH NIH P50** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $1,241,552

## Abstract

This proposal requests 5 years of additional funding for the UCLA Intellectual and Developmental Disabilities
Research Center (IDDRC). For over 40 years, our mission has been to provide an optimal environment for
conducting multidisciplinary research into the mechanisms underlying intellectual and developmental disabilities
(IDDs), to translate these findings into effective treatments for IDDs, and disseminate these findings to the
scientific community and the public. This submission expands on the translational focus that we began 5 years
ago with an added emphasis on human research and clinical trials, and closer ties to the community. Each of
the 5 cores are structured to facilitate interdisciplinary collaborations, following four thematic goals: 1) providing
state of the art infrastructure for IDD related research; 2) encourage innovation by supporting technical
development and providing financial incentives for new projects; 3) promote integration across disciplines, by
encouraging interdisciplinary research among faculty and between cores; and 4) to disseminate advances in
technology to other scientists, train new IDD investigators, and convey findings to the scientific community and
stakeholders in community outreach efforts. We propose 5 interacting cores: A: Administration and
Dissemination, which oversees core functions and usage, assures quality and accountability, and promotes
outreach and dissemination; B: Clinical Translation, supporting clinical trials, recruitment, diagnosis and deep
phenotyping, and biosample collection; C: Genetics, Genomics and BioInformatics, which performs genetic
analysis, sequencing, expression, and provides resources for planning and executing analysis of genomics data;
D: Cells, Circuits and Systems, supporting human iPSC and 3-dimensional organoid development, in- and ex-
vivo electrophysiology and optogenetics; and E: Structural and Functional Visualization, which provides training,
access, and analysis services for in vitro microscopy, mini-cameras for in vivo visualization, animal and human
structural and functional MRI and spectroscopy. Our model research project focuses on mechanisms underlying
sleep impairments in two IDDs, building on new findings from our last submission: a near absence of slow-wave
sleep in Dup15q syndrome. We will examine mechanisms underlying sleep impairments in Dup15q and Rett's
Syndrome using a multidisciplinary approach that includes a clinical component, animal models, and brain
organoid model using patient-derived IPSCs, to elucidate how mechanisms underlying altered sleep physiology
lead to cognitive dysfunction. Results from this project will directly inform next steps for developing interventions
that may modulate sleep and, in turn, neurodevelopment in IDDs.

## Key facts

- **NIH application ID:** 10915519
- **Project number:** 5P50HD103557-05
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** Peyman Golshani
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,241,552
- **Award type:** 5
- **Project period:** 2020-08-01 → 2027-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10915519

## Citation

> US National Institutes of Health, RePORTER application 10915519, UCLA IDDRC (5P50HD103557-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10915519. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*