PROJECT SUMMARY/ABSTRACT – NETWORK COORDINATING CENTER The Network Coordinating Center (NCC) will facilitate and be responsible for network-wide coordination and harmonization of scientific and clinical needs of the funded UG3/UH3 centers comprising the Cancer Adoptive Cellular Therapeutics (Can-ACT) Network. The Network Coordinating Center at Mayo Clinic (NCC-MC) will serve as the administrative hub and coordinating center for all network-related trials and projects. This will include multiple aspects of the functioning of this network, including the administrative and scientific coordination of the Can-ACT Network. The administrative coordination will include (a) providing leadership and facilitating interactions across the network, (b) providing administrative infrastructure to support the activities of the Can-ACT Network, and (c) the coordination of the restricted collaborative funds and administrative supplements for the network. Scientific coordination of this network will include several different critical components, including (a) identifying and establishing strategies for facilitating reagent and specimen sharing, (b) identification and harmonization of process development and manufacturing steps for cell product management and utilization for the functioning of the network between centers and the ICN Core, (c) biostatistical support and collaboration for preclinical and clinical research studies and centralized data management and shared data governance, and (d) bioinformatics and data science support and collaboration. The infrastructure, expertise, and experience of the individuals at Mayo Clinic with national coordination of translational and clinical research is extensive, making this group well-positioned to function as an outstanding coordinating center for the Can-ACT Network. The leadership of this proposed coordinating center brings with them complementary and deep experience and background across these key aims, and they have worked extensively with multi-institutional trials, consortia, and networks as well as cooperative groups in research leadership, trial coordination and implementation, data structures, and importantly development of SOPs and guidance for newly formed collaborative research networks across multiple institutions. Beyond the experience and expertise, the NCC-MC also leverages institutional infrastructure and resources to adapt and evolve as the Can-ACT Network develops and grows through the expected and necessary collaborations across all UG3/UH3 centers and project leaders.