# Clinical Core

> **NIH NIH U54** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $292,819

## Abstract

Project Summary
Acute kidney injury (AKI) is a public health concern with direct impact on clinical and patient-centered outcomes,
and healthcare resource utilization and policy. Recognizing the paucity of breakthrough discoveries in AKI and
the growing burden of this condition, the UAB-UCSD O’Brien Clinical Core (Core A) is designed to reduce the
barriers for investigators to conduct effective clinical and translational research by providing a robust
infrastructure to promote collaborative projects across pre-clinical, clinical and industry researchers. Core A will
provide multifaceted consultation through a customized Project Gateway, access to clinical databases,
available biorepositories, and novel bioinformatics and computational technologies such as the U-BRITE and
Nightingale collaborative digital workspaces in partnership with the Clinical and Translational Science
Awards (CTSA) programs at both institutions for the harmonization and interrogation of big data with a focus
on personalized medicine in AKI. Specifically, Core A will facilitate collaborative digital workspaces for electronic
health record (EHR) data acquisition, transformation, validation, and interrogation. The overarching goal is to
catalyze the translation of bench discoveries to applications that impact human AKI. The Specific Aims are
structured as follows. In Aim 1, we will provide access to clinical data of patients at risk for or with AKI and
consultation for their use. Specifically, we will provide access to curated clinical data from prior clinical studies
hosted by Core A (Aim 1A) and provide access to new harmonized real-world data from the EHR to support
epidemiological surveillance of AKI (e.g., AKI incidence, risk factors and outcomes) and novel clinical research,
including but not limited to AKI risk-classification, sub-phenotyping, and simulated trials (Aim 1B). In Aim 2, we
will provide access to biospecimens of patients at risk for or with AKI and consultation for their use. Specifically,
we will provide access to biospecimens from prior studies hosted by Core A (Aim 2A). In Aim 2B we will provide
a novel platform to link biospecimens of patients at risk for or with AKI with EHR data. Core A will have dynamic
communications and collaborations with the Pre-Clinical Core, the Resource Development Core, and the
O’Brien Kidney Consortium. In this U54 application, we will build upon our expertise and established successes
demonstrated through our currently funded O’Brien Center P30 award. Given our commitment and expertise,
we are confident that Core A will provide innovative resources to the growing research community interested in
AKI-related research.

## Key facts

- **NIH application ID:** 10915658
- **Project number:** 5U54DK137307-02
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **Principal Investigator:** Javier A. Neyra
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $292,819
- **Award type:** 5
- **Project period:** 2023-09-01 → 2028-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10915658

## Citation

> US National Institutes of Health, RePORTER application 10915658, Clinical Core (5U54DK137307-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10915658. Licensed CC0.

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