The proposed renewal is for a continuation of the present Multidisciplinary Training Program in Lung Disease (HL-07185), which provides training in basic and clinical sciences important to the respiratory system. The program draws on the basic and clinical research skills of the broad group of faculty at UCSF addressing questions directly relevant to lung biology and disease. The grant is to accommodate a total of thirteen postdoctoral trainees, including both MD's and PhD's. The main program is an actual research experience under the close supervision of a Preceptor and a review committee selected on the basis of the experimental approaches of the trainee. These approaches include disciplines applicable at the molecular, cellular, tissue, organ, whole animal, clinical, or population levels. In addition, considerable emphasis is placed on special educational opportunities that have been created to prepare individuals for a diverse range of careers in academic medicine. The educational program provides small group conferences and seminars and coursework in basic sciences, biostatistics, epidemiological study design, medical economics, and responsible conduct of research. Training in methods to enhance reproducibility, with an emphasis on rigor in literature review and study design and analysis, appropriate inclusion of important biological variables and authentication of key reagents is woven into all aspects of the training program. Emphasis is placed on personal instruction specifically designed for individual trainees and there is a formalized career development planning process with multiple layers of oversight. Considerable emphasis has been placed on multidisciplinary interaction in research and training, and on developing and implementing academic careers in areas of scientific need, especially in those previously underemphasized. Emerging areas of growth in our program include single cell genomics, synthetic biology, the biology of the microbiome, health disparities and the social determinants of health. An additional important area of emphasis is the recruitment and retention of underrepresented minorities and women in the program. The past and future success of our multidisciplinary program is predicated on a close collaboration among a widely diverse faculty, including clinical and bench-oriented scientists and translating this collaboration to a coordinated approach to research training and career development.