# HABS-HD - Core D - Omics Core

> **NIH NIH U19** · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · 2024 · $6,333,788

## Abstract

HABS-HD OMICS CORE (CORE D) - ABSTRACT
Biofluids, including blood and CSF, alone or in combination, may provide sensitive biomarkers for Alzheimer’s
disease (AD) diagnosis, prognosis, and theragnosis. To date, however, no large-scale systematic multi-level
“omics” study has been conducted in combination with AT(N) defined (amyloid [A], tau [T], neurodegeneration
[N]) biomarkers among African Americans, Mexican Americans, and non-Hispanic whites. Our data suggests
that (1) omics-based biomarkers vary across diverse populations, including plasma AT(N) biomarkers, (2)
omics-based biomarkers can be highly accurate in detecting clinically diagnosed mild cognitive impairment
(MCI) and dementia across populations, but (3) the profiles differ between racial/ethnic groups. More recently,
our data suggests that a proteomic profile is accurate in detecting neurodegeneration, but again the profiles
vary between racial/ethnic groups. Given the documented differences in AT(N) biomarkers by racial/ethnic
groups, it is likely that multi-level omics investigations will highlight novel population-specific pathways for
cognitive decline, MCI and AD. Additionally, with the recent FDA approval of a disease modifying amyloid drug,
the data from the Omics Core (Core D) is more important than ever and can rapidly inform novel, appropriately
tailored, clinical trials. Core D will oversee the collection, processing, assays, storage and distribution of
samples to provide critical data to all Projects (Core – Project Interactions), Cores (Core-Core interactions),
and to global investigators (Cross-Cohort Interactions). Aim 1: Generate high quality genomic data. Aim 2:
Generate high quality proteomic data. Aim 3: Generate high quality exosome data. Aim 4: Generate high
quality metabolomic data. Aim 5: Provide critical omics data for projects (Core-Core, Core-Project
Interactions). Aim 6: Provide data and expertise to external investigators.

## Key facts

- **NIH application ID:** 10916337
- **Project number:** 5U19AG078109-03
- **Recipient organization:** UNIVERSITY OF NORTH TEXAS HLTH SCI CTR
- **Principal Investigator:** LEIGH A JOHNSON
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $6,333,788
- **Award type:** 5
- **Project period:** 2022-09-30 → 2027-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10916337

## Citation

> US National Institutes of Health, RePORTER application 10916337, HABS-HD - Core D - Omics Core (5U19AG078109-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10916337. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*